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Visualizing Dual Presynaptic Inputs using cFork
System |
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| Review Article |
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Exp Neurobiol 2020; 29(3): 177-188
Gene Therapy Options as New Treatment for Inherited Peripheral Neuropathy
Rajarathinam Thenmozhi, Ji-Su Lee, Na Young Park, Byung-Ok Choi, Young Bin Hong |
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| Summary Based on the mode of inheritance, gene therapy for inherited peripheral neuropathy (IPN) can be categorized into three types. For recessively inherited cases, gene replacement can be applied to compensate for the lack of functional protein. For dominantly inherited IPN, a disease modifying gene can be applied, along with silencing the mutant allele. For a copy number variation type of IPN, gene silencing and gene editing-based transcriptional modulation can be applied. |
| Molecular and Cellular Neuroscience |
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Exp Neurobiol 2020; 29(3): 189-206
ERK Regulates NeuroD1-mediated Neurite Outgrowth via Proteasomal Degradation
Tae-young Lee, In-Su Cho, Narayan Bashyal, Francisco J Naya, Ming-Jer Tsai, Jeong Seon Yoon, Jung-Mi Choi, Chang-Hwan Park, Sung-Soo Kim, Haeyoung Suh-Kim |
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| Summary By negatively regulating NeuroD1, Erk maintains the progenitor pools at mid-stage brain develop-ment and promotes glial cell differentiation of progenitor cells at late-stage brain development. |
| Development/Diff erentiation/Regeneration Neuroscience |
| Molecular and Cellular Neuroscience |
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Exp Neurobiol 2020; 29(3): 219-229
Labeling Dual Presynaptic Inputs using cFork Anterograde Tracing System
Jun-Young Oh, Jeong-Ho Han, Hyoeun Lee, Young-Eun Han, Jong Cheol Rah, Hyungju Park |
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| Summary Deciphering complex neural circuit connectivity is essential for understanding how cognitive functions are regulated in the brain. However, currently available tracing tools are not suitable for dissecting multiple synaptic connectivity. This study presents a novel anterograde viral tracing system called “cFork” that allows differential labeling of postsynaptic neurons based on two different presynaptic inputs by adopting anterograde AAV1 and dual gene expression vectors. |
| Development/Diff erentiation/Regeneration Neuroscience |
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Exp Neurobiol 2020; 29(3): 230-248
Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain Injury
Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Shankar S. Iyer, Ramasamy Thangavel, Duraisamy Kempuraj, Sudhanshu P. Raikwar, Kieran Bazley, Kristopher Wu, Asher Khan, Klaudia Kukulka, Bret Bussinger, Smita Zaheer, Casey Burton, Donald James, Asgar Zaheer |
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| Summary Deficiency of glia maturation factor enhances neurotrophic factors, improves behavioral impairments and reduces neuroinflammation after traumatic brain injury in mice. |
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Exp Neurobiol 2020; 29(3): 249-272
Pim-1 Protects Retinal Ganglion Cells by Enhancing Their Regenerative Ability Following Optic Nerve Crush
Shoumei Zhang, Li Shuai, Dong Wang, Tingting Huang, Shengsheng Yang, Mingyong Miao, Fang Liu, Jiajun Xu |
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| Summary Pim-1 overexpression in the retina could activate its Stat3, Akt1 and Akt2 pathways, then inhibit cell apoptosis and promote survival of RGCs via the mitochondrial pathway, and enhance regeneration of injured axons by upregulating βⅢ-tubulin and GAP-43, and ultimately enhance the intrinsic regeneration of RGCs and recovery of visual function. |
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